322 Principal Investigator jobs in Singapore

The National Dental Centre Singapore (NDCS) in collaboration with the National Dental Research Institute Singapore (NDRIS) and Duke-NUS Medical School, is seeking an exceptional Senior Principal Investigator with a focus on oral regeneration and oral developmental biology, particularly in translational applications that advance patient outcomes and clinical innovation. NDCS aims to be a global leader in translational and biomaterials research that transforms oral and craniofacial health.

The successful candidate will be expected to secure national research talent development awards (e.g. NMRC Singapore Translational Research Investigator Award or Clinical Scientist Award), obtain competitive extramural research funding, and establish a robust, independent research programme that bridges basic science with clinical application in the field of oral regeneration and developmental biology. Areas of strategic interest include regenerative biomaterials, stem cell therapies, immunomodulation in oral wound healing, lab-on-chip model sand applications, molecular mechanisms of oral tissue development and repair, and the use of AI in tissue regeneration and biomaterials design.

The candidate is expected to foster strong collaborations with clinical and scientific leaders within the SingHealth Duke-NUS Academic Medical Centre, and internationally. Access will be provided to state-of-the-art research infrastructure within the Academic Medical Centre, including translational platforms, core imaging, bioinformatics core facility, advanced bioimaging facility, excellent supercomputing facility, and the national large animal research facility. The candidate will also supervise and mentor graduate students, clinician-scientists, and junior investigators, contributing to research talent development in the field.

Requirements:

• Ph.D. in biomedical sciences, tissue engineering, biomaterials, cell biology, developmental biology, or a related field.
• Doctor of Dental Surgery (DDS) or Masters of Dental Surgery (MDS), registrable with the Singapore Dental Council.
• Outstanding research track record in oral regeneration, biomaterials, cell biology, developmental biology, or related translational disciplines.
• Demonstrated success in securing competitive national or international research grants.
• Strong publication record in high-impact peer-reviewed journals.
• Proven leadership in supervising PhD/Masters students and managing research teams.
• Ability to attract or engage with industry collaborators is highly desirable.
• Excellent written, oral communication and interpersonal skills.

Interested candidates are invited to submit their CV and your research statement.

Be part of a dynamic and pioneering research environment at NDCS, NDRIS and Duke-NUS, where discovery meets impact in advancing oral health globally.

National Dental Centre Singapore (NDCS)/National Dental Research Institute Singapore (NDRIS) seeks an exceptionally promising and accomplished Senior Principal Investigator (PI) with a strong track record in oral microbiome and/or oral microbiology research augmented by advanced proficiency in multi-omics methodologies. The ideal candidate will spearhead a high-impact, externally funded research agenda aimed at deciphering oral-systemic health connections and innovating prevention, diagnostic and therapeutic modalities.

NDCS/NDRIS is a leader in clinical, translational and health services research, committed to shaping the future of oral healthcare.

The key responsibilities of the successful candidate:

• Secure, establish and lead a competitive, externally funded research programme integrating oral microbiology with multi-omics approaches
• Pioneer insights into the associations between oral microbiome signatures and systemic health, develop novel prevention, diagnostics and treatment strategies
• Build upon platforms such as the Singapore Oral Multiomics Initiative (SOMI), which currently supports metagenomics, proteomics, metabolomics and epigenomics research
• Synergize and/or collaborate with existing clinical and research faculty within the SingHealth Duke-NUS Academic Medical Centre, as well as foster new collaborations with other internationally renowned clinicians and researchers to elevate the research profile and global impact.
• Identify and pursue diverse funding opportunities to bolster research infrastructure and clinical studies at NDCS/NDRIS
• Demonstrate exceptional scholarly achievements through peer-reviewed publications, competitive grants, patents and other scholarly outputs
• Supervise, mentor and nurture PhD and Master's students, dental residents/officers, research staff and clinical investigators, to hone and develop their research skills and capabilities.
• Oversee laboratory operations, ensuring adherence to safety protocols (biological, chemical, radioactive, fire safety) and regulatory standards (e.g. IBC, IACUC, SG-GCP, HAS, etc); and uphold the highest standards of laboratory safety, regulatory compliance and research integrity.

Requirements:

• Ph.D. in microbiology or related fields.
• Preferably with Bachelor of Dental Surgery (BDS), Masters of Dental Surgery (MDS) or equivalent dgrees, recognized and registrable with the Singapore Dental Council.
• Excellent academic track record in scientific publications, competitive extramural grants, patents, supervision of PhD/Masters students, etc.
• Demonstrated ability to attract industry funding will be an advantage.
• Excellent written and oral communication skills.
• Excellent interpersonal and leadership skills

• Monitor and respond to whistleblower complaints in a timely and confidential manner.
• Maintain and review the whistleblowing case log to ensure adherence to established timelines and protocols.
• Conduct case reviews and provide periodic reports on whistleblowing trends and outcomes.
• Promote awareness of whistleblowing channels through employee communication and training.
• Support internal audit assignments and provide input on control design and governance improvements.
• Collaborate with internal stakeholders on disciplinary or remedial actions.

• Bachelor's degree in Accountancy, Finance, Law, Business, Compliance or a related field.
• Minimum 6-10 years of relevant experience in investigations, audit or compliance.
• Strong understanding of governance, risk and internal control frameworks.
• Proficient in Microsoft Office and data analytics tools.
• Strong report writing, interviewing and analytical skills.

The laboratories of Professor Chen Xiaoyuan and Professor Giorgia Pastorin at the National University are seeking a Postdoctoral Researcher to work on a funded research project.

Our team is looking for a motivated post-doctoral researcher to contribute to a project promoting in situ T cell engineering by delivering mRNA into spleen, which has the potential to boost the body's immune response given its crucial role in kickstarting the immune system.

Candidates will have the opportunity to collaborate with a multidisciplinary team and international partners.

Responsibilities include:

• Developing and executing experiments.
• Collecting and analyzing data.
• Guiding and working with junior staff members, including students.
• Contributing to the preparation of manuscripts and reports.
• Ensuring research integrity and safety compliance.

Faculty positions at the A*STAR Bioinformatics Institute (A*STAR BII)

The Agency for Science, Technology and Research Bioinformatics Institute (A*STAR BII) is seeking outstanding and visionary 1) early-career and 2) senior faculty candidates to lead cutting-edge and mission-oriented research programs in biomolecular and biomedical data science. As the leading computational biology and biomedical informatics research institute in Singapore, A*STAR BII is dedicated to creating value from data to accelerate discovery, improve health, and drive economic growth. We derive actionable insights from a wide spectrum of biological and biomedical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images using AI/ML-based and other computation techniques.

Strategically aligned with A*STAR role as Singapore Strategic Innovation Engine, A*STAR BII focuses on strategic areas such as precision health, synthetic biology, cellular biotech, and drug discovery. Through our strategic initiatives, such as AI for Drug Discovery together with the national platform Experimental Drug Development Center (EDDC), A*STAR BII galvanizes a robust biomedical research ecosystem aimed at clinical and economic impact. Our talent development efforts in bioinformatics and data analytics contribute significantly to Singapore standing as a global leader in biomedical research and technology.

We are seeking highly motivated experts passionate about biomedical and clinical applications and the translation of technologies to improve healthcare and/or societal outcomes.

This role is ideal for candidates who want to build and lead impactful, data-driven research teams. The ideal candidate will demonstrate a strong commitment to both advancing cutting-edge computational data science and an innovative, application-oriented mindset for real-world applications in healthcare.

Job scope and responsibilities :

A. Lead a dynamic research team specializing in one of the following high-impact areas. Experts from other related areas are also welcome to apply.

• Quantum Computing for biology and biomedical applications.
• AI in drug discovery with relevant industry experience.
• AI for healthcare and biomedical science.
• AI and generative foundation models: Synthetic data, Agentic AI and Clinical and multi-omics data analysis with deep expertise specific disease area(s).
• Synthetic biology, including, e.g., AI-driven (bio)retrosynthesis and metabolic modelling, and (agentic) AI approaches to the Design-Build-Test-Learn cycle of microbial strain engineering.

B. Forge strong partnerships with clinicians and with other faculty members within A*STAR and the local ecosystem to realise synergies in research.

C. Collaborate with industrial partners to translate computational advances into real-world practice.

D. Lead and actively participate in external competitive research grants.

Job Requirements:

• PhD or equivalent doctoral degree in a relevant field (e.g., Bioinformatics, Computational Biology, Computer Science, Data Science, or a related discipline) with at least 15 years of relevant experience.
• An exceptional track record of research accomplishments, evidenced by a strong publication and citation record (e.g. Clarivate highly cited, FWCI > 2).
• Excellent communication (oral and written) and public speaking skills.
• Demonstrated strategic thinking ability and a clear vision for innovative research.
• A strong interest in both developing cutting-edge computational data science and driving innovation to improve healthcare outcomes.
• Evidence of the ability to collaborate effectively with researchers from diverse backgrounds, including clinicians and industry partners.
• Track record of entrepreneurship and/or technology transfer activities is preferred.
• Experience in leading and mentoring research teams is highly desirable.

Interested applicants please send your application package to the Faculty Search committee:

Application package should consist of:

• Curriculum Vitae which should include a list of publications, patents, grants (including amount received), industry collaborations and licensing, if any.
• Research Statement (2-page) consisting of two parts: Summarize any exposure to soving real-world biological problems (wet lab collab, pharma/healthcare experience, etc.). Your vision for a new cool project or product at the intersection of AI and biology.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Faculty positions at the A*STAR Bioinformatics Institute (A*STAR BII)

The Agency for Science, Technology and Research Bioinformatics Institute (A*STAR BII) is seeking outstanding and visionary 1) early-career and 2) senior faculty candidates to lead cutting-edge and mission-oriented research programs in biomolecular and biomedical data science. As the leading computational biology and biomedical informatics research institute in Singapore, A*STAR BII is dedicated to creating value from data to accelerate discovery, improve health, and drive economic growth. We derive actionable insights from a wide spectrum of biological and biomedical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images using AI/ML-based and other computation techniques.

Strategically aligned with A*STAR role as Singapore Strategic Innovation Engine, A*STAR BII focuses on strategic areas such as precision health, synthetic biology, cellular biotech, and drug discovery. Through our strategic initiatives, such as AI for Drug Discovery together with the national platform Experimental Drug Development Center (EDDC), A*STAR BII galvanizes a robust biomedical research ecosystem aimed at clinical and economic impact. Our talent development efforts in bioinformatics and data analytics contribute significantly to Singapore standing as a global leader in biomedical research and technology.

We are seeking highly motivated experts passionate about biomedical and clinical applications and the translation of technologies to improve healthcare and/or societal outcomes.

This role is ideal for candidates who want to build and lead impactful, data-driven research teams. The ideal candidate will demonstrate a strong commitment to both advancing cutting-edge computational data science and an innovative, application-oriented mindset for real-world applications in healthcare.

Job scope and responsibilities :

A. Lead a dynamic research team specializing in one of the following high-impact areas. Experts from other related areas are also welcome to apply.

• Quantum Computing for biology and biomedical applications.
• AI in drug discovery with relevant industry experience.
• AI for healthcare and biomedical science.
• AI and generative foundation models: Synthetic data, Agentic AI and Clinical and multi-omics data analysis with deep expertise specific disease area(s).
• Synthetic biology, including, e.g., AI-driven (bio)retrosynthesis and metabolic modelling, and (agentic) AI approaches to the Design-Build-Test-Learn cycle of microbial strain engineering.

B. Forge strong partnerships with clinicians and with other faculty members within A*STAR and the local ecosystem to realise synergies in research.

C. Collaborate with industrial partners to translate computational advances into real-world practice.

D. Lead and actively participate in external competitive research grants.

Job Requirements:

• PhD or equivalent doctoral degree in a relevant field (e.g., Bioinformatics, Computational Biology, Computer Science, Data Science, or a related discipline) with at least 12 years of relevant experience.
• An exceptional track record of research accomplishments, evidenced by a strong publication and citation record (e.g. Clarivate highly cited, FWCI > 2).
• Excellent communication (oral and written) and public speaking skills.
• Demonstrated strategic thinking ability and a clear vision for innovative research.
• A strong interest in both developing cutting-edge computational data science and driving innovation to improve healthcare outcomes.
• Evidence of the ability to collaborate effectively with researchers from diverse backgrounds, including clinicians and industry partners.
• Track record of entrepreneurship and/or technology transfer activities is preferred.
• Experience in leading and mentoring research teams is highly desirable.

Interested applicants please send your application package to the Faculty Search committee:

Application package should consist of:

• Curriculum Vitae which should include a list of publications, patents, grants (including amount received), industry collaborations and licensing, if any.
• Research Statement (2-page) consisting of two parts: Summarize any exposure to soving real-world biological problems (wet lab collab, pharma/healthcare experience, etc.). Your vision for a new cool project or product at the intersection of AI and biology.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Faculty positions at the A*STAR Bioinformatics Institute (A*STAR BII)

The Agency for Science, Technology and Research Bioinformatics Institute (A*STAR BII) is seeking outstanding and visionary 1) early-career and 2) senior faculty candidates to lead cutting-edge and mission-oriented research programs in biomolecular and biomedical data science. As the leading computational biology and biomedical informatics research institute in Singapore, A*STAR BII is dedicated to creating value from data to accelerate discovery, improve health, and drive economic growth. We derive actionable insights from a wide spectrum of biological and biomedical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images using AI/ML-based and other computation techniques.

Strategically aligned with A*STAR role as Singapore Strategic Innovation Engine, A*STAR BII focuses on strategic areas such as precision health, synthetic biology, cellular biotech, and drug discovery. Through our strategic initiatives, such as AI for Drug Discovery together with the national platform Experimental Drug Development Center (EDDC), A*STAR BII galvanizes a robust biomedical research ecosystem aimed at clinical and economic impact. Our talent development efforts in bioinformatics and data analytics contribute significantly to Singapore standing as a global leader in biomedical research and technology.

We are seeking highly motivated experts passionate about biomedical and clinical applications and the translation of technologies to improve healthcare and/or societal outcomes.

This role is ideal for candidates who want to build and lead impactful, data-driven research teams. The ideal candidate will demonstrate a strong commitment to both advancing cutting-edge computational data science and an innovative, application-oriented mindset for real-world applications in healthcare.

Job scope and responsibilities :

A. Lead a dynamic research team specializing in one of the following high-impact areas. Experts from other related areas are also welcome to apply.

• Quantum Computing for biology and biomedical applications.
• AI in drug discovery with relevant industry experience.
• AI for healthcare and biomedical science.
• AI and generative foundation models: Synthetic data, Agentic AI and Clinical and multi-omics data analysis with deep expertise specific disease area(s).
• Synthetic biology, including, e.g., AI-driven (bio)retrosynthesis and metabolic modelling, and (agentic) AI approaches to the Design-Build-Test-Learn cycle of microbial strain engineering.

B. Forge strong partnerships with clinicians and with other faculty members within A*STAR and the local ecosystem to realise synergies in research.

C. Collaborate with industrial partners to translate computational advances into real-world practice.

D. Lead and actively participate in external competitive research grants.

Job Requirements:

• PhD or equivalent doctoral degree in a relevant field (e.g., Bioinformatics, Computational Biology, Computer Science, Data Science, or a related discipline) with at least 8 years of relevant experience.
• An exceptional track record of research accomplishments, evidenced by a strong publication and citation record (e.g. Clarivate highly cited, FWCI > 2).
• Excellent communication (oral and written) and public speaking skills.
• Demonstrated strategic thinking ability and a clear vision for innovative research.
• A strong interest in both developing cutting-edge computational data science and driving innovation to improve healthcare outcomes.
• Evidence of the ability to collaborate effectively with researchers from diverse backgrounds, including clinicians and industry partners.
• Track record of entrepreneurship and/or technology transfer activities is preferred.
• Experience in leading and mentoring research teams is highly desirable.

Interested applicants please send your application package to the Faculty Search committee:

Application package should consist of:

• Curriculum Vitae which should include a list of publications, patents, grants (including amount received), industry collaborations and licensing, if any.
• Research Statement (2-page) consisting of two parts: Summarize any exposure to soving real-world biological problems (wet lab collab, pharma/healthcare experience, etc.). Your vision for a new cool project or product at the intersection of AI and biology.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

National Dental Centre Singapore (NDCS)/National Dental Research Institute Singapore (NDRIS) seeks an exceptionally promising and accomplished Senior Principal Investigator (PI) with a strong track record in oral microbiome and/or oral microbiology research augmented by advanced proficiency in multi-omics methodologies. The ideal candidate will spearhead a high-impact, externally funded research agenda aimed at deciphering oral-systemic health connections and innovating prevention, diagnostic and therapeutic modalities.

NDCS/NDRIS is a leader in clinical, translational and health services research, committed to shaping the future of oral healthcare.

The key responsibilities of the successful candidate:

• Secure, establish and lead a competitive, externally funded research programme integrating oral microbiology with multi-omics approaches
• Pioneer insights into the associations between oral microbiome signatures and systemic health, develop novel prevention, diagnostics and treatment strategies
• Build upon platforms such as the Singapore Oral Multiomics Initiative (SOMI), which currently supports metagenomics, proteomics, metabolomics and epigenomics research
• Synergize and/or collaborate with existing clinical and research faculty within the SingHealth Duke-NUS Academic Medical Centre, as well as foster new collaborations with other internationally renowned clinicians and researchers to elevate the research profile and global impact.
• Identify and pursue diverse funding opportunities to bolster research infrastructure and clinical studies at NDCS/NDRIS
• Demonstrate exceptional scholarly achievements through peer-reviewed publications, competitive grants, patents and other scholarly outputs
• Supervise, mentor and nurture PhD and Master’s students, dental residents/officers, research staff and clinical investigators, to hone and develop their research skills and capabilities.
• Oversee laboratory operations, ensuring adherence to safety protocols (biological, chemical, radioactive, fire safety) and regulatory standards (e.g. IBC, IACUC, SG-GCP, HAS, etc); and uphold the highest standards of laboratory safety, regulatory compliance and research integrity.

Requirements:

• Ph.D. in microbiology or related fields.
• Preferably with Bachelor of Dental Surgery (BDS), Masters of Dental Surgery (MDS) or equivalent dgrees, recognized and registrable with the Singapore Dental Council.
• Excellent academic track record in scientific publications, competitive extramural grants, patents, supervision of PhD/Masters students, etc.
• Demonstrated ability to attract industry funding will be an advantage.
• Excellent written and oral communication skills.
• Excellent interpersonal and leadership skills

The National Dental Centre Singapore (NDCS), in collaboration with the National Dental Research Institute Singapore (NDRIS) and Duke-NUS Medical School, is seeking an exceptional Senior Principal Investigator with a focus on oral regeneration and oral developmental biology, particularly in translational applications that advance patient outcomes and clinical innovation. NDCS aims to be a global leader in translational and biomaterials research that transforms oral and craniofacial health.

The successful candidate will be expected to secure national research talent development awards (e.g. NMRC Singapore Translational Research Investigator Award or Clinical Scientist Award), obtain competitive extramural research funding, and establish a robust, independent research programme that bridges basic science with clinical application in the field of oral regeneration and developmental biology. Areas of strategic interest include regenerative biomaterials, stem cell therapies, immunomodulation in oral wound healing, lab-on-chip model sand applications, molecular mechanisms of oral tissue development and repair, and the use of AI in tissue regeneration and biomaterials design.

The candidate is expected to foster strong collaborations with clinical and scientific leaders within the SingHealth Duke-NUS Academic Medical Centre, and internationally. Access will be provided to state-of-the-art research infrastructure within the Academic Medical Centre, including translational platforms, core imaging, bioinformatics core facility, advanced bioimaging facility, excellent supercomputing facility, and the national large animal research facility. The candidate will also supervise and mentor graduate students, clinician-scientists, and junior investigators, contributing to research talent development in the field.

Requirements:

• Ph.D. in biomedical sciences, tissue engineering, biomaterials, cell biology, developmental biology, or a related field
• Doctor of Dental Surgery (DDS) or Masters of Dental Surgery (MDS), registrable with the Singapore Dental Council
• Outstanding research track record in oral regeneration, biomaterials, cell biology, developmental biology, or related translational disciplines
• Demonstrated success in securing competitive national or international research grants
• Strong publication record in high-impact peer-reviewed journals
• Proven leadership in building and directing multidisciplinary research teams, developing institutional research capacity, and shaping strategic research agendas
• Proven leadership in supervising PhD/Masters students and managing research teams
• Ability to attract or engage with industry collaborators is highly desirable
• Excellent written, oral communication, and interpersonal skills

Interested candidates are invited to submit their CV and your research statement.

Be part of a dynamic and pioneering research environment at NDCS, NDRIS and Duke- NUS, where discovery meets impact in advancing oral health globally.