183 Principal Investigator jobs in Singapore

We are seeking a highly motivated Microbiome Research Scientist to join our interdisciplinary team.

• Job Description: The successful candidate will contribute to the mechanistic understanding of microbial influence on liver cancer development and therapeutic response.
• Key Responsibilities:
1. Design and perform microbiological and molecular biology experiments.
2. Culture and characterize bacterial and/or viral agents implicated in liver disease progression or therapy response.
3. Work with mouse models of HCC, including microbiota-colonized and germ-free systems.
4. Design and execute microbiota transfer or metabolite supplementation experiments in mouse models (e.g., germ-free or tumor models) and monitor tumor development, liver pathology, and immune/metabolic responses.
5. Collaborate with investigators across disciplines, including cancer biology, microbiome research, immunology, and clinical hepatology.
6. Interpret profiling data using domain knowledge in microbiome.
7. Analyze experimental results and draw meaningful conclusions.
8. Lead publication and grant application effort alongside PI.

• PhD (or MSc with strong research experience) in Microbiology, Molecular Biology, or related discipline.
• Experience with the following is essential:
1. Flow cytometry, ELISA, and/or immunohistochemistry.
2. Microbiology or host–microbe interaction research, ideally with relevance to cancer, liver diseases, or inflammation.
3. Microbial culture, molecular techniques (e.g., DNA/RNA extraction, qPCR, PCR, gel electrophoresis), and cell-based assays.
4. Animal models, especially germ-free or humanised mouse models.

Benefits: The role offers a unique opportunity to contribute to cutting-edge cancer biology research, with the potential to directly impact therapeutic strategies for HCC patients.

What We Offer: A dynamic and collaborative research environment, working closely with bioinformaticians, clinicians, and researchers involved in ongoing clinical trials.

SIFBI seeks to appoint a Principal Investigator in the areas of food oral processing and sensory perception, including psychophysics, sensory physiology, sensory nutrition, and neural behaviour of eating and sensory perception, and other emerging topics in relation to eating and sensory perception. The appointed Principal Investigator is expected to lead a research team to conduct experiment-based original research in his/her expert area.

The candidate should hold a PhD degree in food science, sensory science, or other relevant disciplines and appropriate experience of independent research either as an academic or an industrial researcher. The candidate should demonstrate his/her research achievements with an excellent track record of research publications, cases of successful funding, industrial collaborations, and social and economic impacts. Experience in research management and strategy planning is highly desirable.

Informal enquiry can be made by contacting Prof. Jianshe Chen via email

Job Description & Requirement:

SIFBI seeks to appoint a Principal Investigator in the areas of food oral processing and sensory perception, including psychophysics, sensory physiology, sensory nutrition, and neural behaviour of eating and sensory perception, and other emerging topics in relation to eating and sensory perception. The appointed Principal Investigator is expected to lead a research team to conduct experiment-based original research in his/her expert area.

The candidate should hold a PhD degree in food science, sensory science, or other relevant disciplines and appropriate experience of independent research either as an academic or an industrial researcher. The candidate should demonstrate his/her research achievements with an excellent track record of research publications, cases of successful funding, industrial collaborations, and social and economic impacts. Experience in research management and strategy planning is highly desirable.

Informal enquiry can be made by contacting Prof. Jianshe Chen via email

National Dental Centre Singapore (NDCS)/National Dental Research Institute Singapore (NDRIS) seeks an exceptionally promising and accomplished Senior Principal Investigator (PI) with a strong track record in oral microbiome and/or oral microbiology research augmented by advanced proficiency in multi-omics methodologies. The ideal candidate will spearhead a high-impact, externally funded research agenda aimed at deciphering oral-systemic health connections and innovating prevention, diagnostic and therapeutic modalities.

NDCS/NDRIS is a leader in clinical, translational and health services research, committed to shaping the future of oral healthcare.

The key responsibilities of the successful candidate:

• Secure, establish and lead a competitive, externally funded research programme integrating oral microbiology with multi-omics approaches
• Pioneer insights into the associations between oral microbiome signatures and systemic health, develop novel prevention, diagnostics and treatment strategies
• Build upon platforms such as the Singapore Oral Multiomics Initiative (SOMI), which currently supports metagenomics, proteomics, metabolomics and epigenomics research
• Synergize and/or collaborate with existing clinical and research faculty within the SingHealth Duke-NUS Academic Medical Centre, as well as foster new collaborations with other internationally renowned clinicians and researchers to elevate the research profile and global impact.
• Identify and pursue diverse funding opportunities to bolster research infrastructure and clinical studies at NDCS/NDRIS
• Demonstrate exceptional scholarly achievements through peer-reviewed publications, competitive grants, patents and other scholarly outputs
• Supervise, mentor and nurture PhD and Master’s students, dental residents/officers, research staff and clinical investigators, to hone and develop their research skills and capabilities.
• Oversee laboratory operations, ensuring adherence to safety protocols (biological, chemical, radioactive, fire safety) and regulatory standards (e.g. IBC, IACUC, SG-GCP, HAS, etc); and uphold the highest standards of laboratory safety, regulatory compliance and research integrity.

Requirements:

• Ph.D. in microbiology or related fields.
• Preferably with Bachelor of Dental Surgery (BDS), Masters of Dental Surgery (MDS) or equivalent dgrees, recognized and registrable with the Singapore Dental Council.
• Excellent academic track record in scientific publications, competitive extramural grants, patents, supervision of PhD/Masters students, etc.
• Demonstrated ability to attract industry funding will be an advantage.
• Excellent written and oral communication skills.
• Excellent interpersonal and leadership skills

A*STAR’s Strategic Research and Translational Thrusts (SRTTs) are mission-focused programmes in strategic and emerging areas that are cross-disciplinary and of wider strategic interest to A*STAR and Singapore. Set up to address ambitious technological challenges towards impactful outcomes, each SRTT is led by a Programme Director (PD) and is centrally facilitated and supported by A*STAR HQ.

The Singapore Integrative Biosystems & Engineering Research (SIBER) SRTT harnesses synthetic biology capabilities to aid the sustainable transformation of Singapore’s Energy & Chemicals sector with the aim to expand to other sectors. It will create a synthetic biology platform initially for sustainable chemicals and fuels, powered by a unique organism library utilising the biodiversity of Singapore. SIBER’s vision is to be a premier hub in industrial biotechnology innovation for the energy / chemicals as well as other sectors, empowering Singapore to seize opportunities in the future bioeconomy.

We are looking for a Principal Investigator with expertise in metabolic engineering to join our laboratory in A*STAR SIBER SRTT.

Job Description:

• Lead, design and perform experiments involving cutting-edge strain engineering and / or metabolic engineering harnessing synthetic biology and engineering biology approaches for the production of high-value chemicals in microbial cell factories. This also includes, for example, aspects of laboratory automation, protein biochemistry, cell-free systems, biosensing, biosynthesis pathway assembly.
• Develop applied research, translational and commercialisation strategies, in coordination with the SRTT leadership team.
• Work closely with the other SIBER SRTT team members as well as other relevant research institutes in A*STAR.
• Apply for individual research grants as part of career development and apply proactively for other research proposals.
• Present findings at seminars, meetings and national / international conferences.
• Write manuscripts for publication.
• Contribute to mentorship of PDRA, students, interns and technicians in the laboratory.
• Be an excellent communicator and team player.
• Build and maintain strong relationships with local and international research network

Requirements:

• PhD in Life Sciences, Biology, Biochemistry or a related field.
• At least more than 15 years of postdoc experience or independent research experience and leading a research team.
• Strong background in synthetic biology / engineering biology, molecular biology, biochemistry, chemical engineering, with a demonstrated capability for developing and implementing independent research activities at the cutting edge of the field.
• Track record of peer-reviewed scientific publications with at least five first-authored or last-authored papers in internationally recognised journals.
• Think methodically and have dedication, motivation, creativity and passion for scientific research and continuous learning.
• Exceptional analytical, experimental design, technical and problem-solving skills.
• Proficiency in communication by doing so in a straightforward and accurate manner, writing and editing scientific documents.
• Demonstrated ability to work independently as well as collaboratively and efficiently in an interdisciplinary team.
• Strong supervisory skills.
• A strong interest in the translational and applied aspects of research, including collaborations with industrial partners.
• Experience in omics technologies, HTP automation facilities, data analysis using various software, Design of Experiments and programming will be a plus.

We offer:

• A well-funded laboratory supported by A*STAR, the National Research Foundation (NRF) and industry to pursue a combination of exciting projects and your scientific interests.
• A nurturing, supportive and stimulating environment with close mentorship to develop your scientific career.
• Access to state-of-the-art technologies, scientific resources, core facilities and infrastructure housed within A*STAR to facilitate your research work.
• Access to collaborations with industrial partners to translate research findings to commercial applications and societal impact.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A*STAR’s Strategic Research and Translational Thrusts (SRTTs) are mission-focused programmes in strategic and emerging areas that are cross-disciplinary and of wider strategic interest to A*STAR and Singapore. Set up to address ambitious technological challenges towards impactful outcomes, each SRTT is led by a Programme Director (PD) and is centrally facilitated and supported by A*STAR HQ.

The Singapore Integrative Biosystems & Engineering Research (SIBER) SRTT harnesses synthetic biology capabilities to aid the sustainable transformation of Singapore’s Energy & Chemicals sector with the aim to expand to other sectors. It will create a synthetic biology platform initially for sustainable chemicals and fuels, powered by a unique organism library utilising the biodiversity of Singapore. SIBER’s vision is to be a premier hub in industrial biotechnology innovation for the energy / chemicals as well as other sectors, empowering Singapore to seize opportunities in the future bioeconomy.

We are looking for a Principal Investigator/Senior Principal Scientist/Senior Research Fellow with expertise in metabolic engineering to join our laboratory in A*STAR SIBER SRTT.

Job Description:

• Lead, design and perform experiments involving cutting-edge strain engineering and / or metabolic engineering harnessing synthetic biology and engineering biology approaches for the production of high-value chemicals in microbial cell factories. This also includes, for example, aspects of laboratory automation, protein biochemistry, cell-free systems, biosensing, biosynthesis pathway assembly.
• Develop applied research, translational and commercialisation strategies, in coordination with the SRTT leadership team.
• Work closely with the other SIBER SRTT team members as well as other relevant research institutes in A*STAR.
• Apply for individual research grants as part of career development and apply proactively for other research proposals.
• Present findings at seminars, meetings and national / international conferences.
• Write manuscripts for publication.
• Contribute to mentorship of PDRA, students, interns and technicians in the laboratory.
• Be an excellent communicator and team player.
• Build and maintain strong relationships with local and international research network

Requirements:

• PhD in Life Sciences, Biology, Biochemistry or a related field.
• At least more than 12 years of postdoc experience or independent research experience and leading a research team.
• Strong background in synthetic biology / engineering biology, molecular biology, biochemistry, chemical engineering, with a demonstrated capability for developing and implementing independent research activities at the cutting edge of the field.
• Track record of peer-reviewed scientific publications with at least five first-authored or last-authored papers in internationally recognised journals.
• Think methodically and have dedication, motivation, creativity and passion for scientific research and continuous learning.
• Exceptional analytical, experimental design, technical and problem-solving skills.
• Proficiency in communication by doing so in a straightforward and accurate manner, writing and editing scientific documents.
• Demonstrated ability to work independently as well as collaboratively and efficiently in an interdisciplinary team.
• Strong supervisory skills.
• A strong interest in the translational and applied aspects of research, including collaborations with industrial partners.
• Experience in omics technologies, HTP automation facilities, data analysis using various software, Design of Experiments and programming will be a plus.

We offer:

• A well-funded laboratory supported by A*STAR, the National Research Foundation (NRF) and industry to pursue a combination of exciting projects and your scientific interests.
• A nurturing, supportive and stimulating environment with close mentorship to develop your scientific career.
• Access to state-of-the-art technologies, scientific resources, core facilities and infrastructure housed within A*STAR to facilitate your research work.
• Access to collaborations with industrial partners to translate research findings to commercial applications and societal impact.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

SIBER SRTT PI position in Computational biology or Systems biology for initially 3 years with a possibility to extend the appointment for an additional 2 years.

A*STAR Strategic Research and Translational Thrusts (SRTTs) are mission-focused programmes in strategic and emerging areas that are cross-disciplinary and of wider strategic interest to A*STAR and Singapore. Set up to address ambitious technological challenges towards impactful outcomes, each SRTT is led by a Programme Director (PD) and is centrally facilitated and supported by A*STAR HQ.

The Singapore Integrative Biosystems & Engineering Research (SIBER) SRTT harnesses synthetic biology capabilities to aid the sustainable transformation of Singapore’s Energy & Chemicals sector with the aim to expand to other sectors. It will create a synthetic biology platform initially for sustainable chemicals and fuels, powered by a unique organism library utilising the biodiversity of Singapore. SIBER’s vision is to be a premier hub in industrial biotechnology innovation for the energy / chemicals as well as other sectors, empowering Singapore to seize opportunities in the future bioeconomy.

We are looking for a PI (senior research fellow or senior principal scientist) with expertise in computational biology or systems biology to join our laboratory in A*STAR SIBER SRTT.

Job Description:

• Lead, design and perform the development and application of state-of-the-art computational tools to direct and inform the microbial strain engineering and metabolic engineering activities of the SIBER SRTT experimental team to produce high-value chemicals in microbial cell factories. This includes, for example, computational approaches to genome mining and retro(bio)synthesis, metabolic pathway modelling and optimisation, protein structure design for novel and improved biochemical functionalities, and the analysis of omics profiles of engineered strains to drive further iterations of the design cycle. All of these should be empowered by the latest advances in artificial intelligence and machine learning (AI/ML) where appropriate.
• Develop applied research, translational and commercialisation strategies, in coordination with the SRTT leadership team.
• Work closely with the other SIBER SRTT team members across disciplines
• Apply for individual research grants as part of career development and apply proactively for research proposals.
• Present findings at seminars, meetings and national / international conferences
• Write manuscripts for publication.
• Contribute to mentorship of PDRAs, students, interns and technicians in the laboratory
• Be an excellent communicator and team player.
• Build and maintain strong relationships with local and international research network.

Requirements:

• PhD in Computational Biology, Systems Biology, Bioinformatics, Cheminformatics, or a related field.
• At least more than 12 years of postdoc experience or independent research experience and leading a research team.
• Strong background in current developments in computational biology and systems biology, including relevant aspects of AI/ML, with demonstrated capability for independently developing and applying state-of-the-art tools for concrete biological applications at the cutting edge of the field.
• Extensive understanding of the key concepts and techniques of synthetic biology / engineering biology, molecular biology, biochemistry, chemical engineering, and process engineering.
• Track record of peer-reviewed scientific publications with at least five first-authored or last-authored papers in internationally recognised journals.
• Dedication, motivation, creativity and passion for scientific research and continuous learning.
• Exceptional analytical, experimental design, technical and problem-solving skills.
• Proficiency in communication, writing and editing scientific documents.
• Demonstrated ability to work independently as well as collaboratively and efficiently in an interdisciplinary team.
• Strong supervisory skills.
• A strong interest in the translational and applied aspects of research, including collaborations with industrial partners.
• Experience in omics technologies, HTP automation facilities, data analysis using various software, state-of-art med-scale fermenters or scale-up fermenters and programming will be a plus.

We offer:

• A well-funded laboratory supported by A*STAR, the National Research Foundation (NRF) and industry to pursue a combination of exciting projects and your scientific interests.
• A nurturing, supportive and stimulating environment with close mentorship to develop your scientific career.
• Access to state-of-the-art technologies, scientific resources, core facilities and infrastructure housed within A*STAR to facilitate your research work.
• Access to collaborations with industrial partners to translate research findings to commercial applications and societal impact.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

SIBER SRTT PI position in Computational biology or Systems biology for initially 3 years with a possibility to extend the appointment for an additional 2 years.

A*STAR Strategic Research and Translational Thrusts (SRTTs) are mission-focused programmes in strategic and emerging areas that are cross-disciplinary and of wider strategic interest to A*STAR and Singapore. Set up to address ambitious technological challenges towards impactful outcomes, each SRTT is led by a Programme Director (PD) and is centrally facilitated and supported by A*STAR HQ.

The Singapore Integrative Biosystems & Engineering Research (SIBER) SRTT harnesses synthetic biology capabilities to aid the sustainable transformation of Singapore’s Energy & Chemicals sector with the aim to expand to other sectors. It will create a synthetic biology platform initially for sustainable chemicals and fuels, powered by a unique organism library utilising the biodiversity of Singapore. SIBER’s vision is to be a premier hub in industrial biotechnology innovation for the energy / chemicals as well as other sectors, empowering Singapore to seize opportunities in the future bioeconomy.

We are looking for a PI (senior research fellow or senior principal scientist) with expertise in computational biology or systems biology to join our laboratory in A*STAR SIBER SRTT.

Job Description:

• Lead, design and perform the development and application of state-of-the-art computational tools to direct and inform the microbial strain engineering and metabolic engineering activities of the SIBER SRTT experimental team to produce high-value chemicals in microbial cell factories. This includes, for example, computational approaches to genome mining and retro(bio)synthesis, metabolic pathway modelling and optimisation, protein structure design for novel and improved biochemical functionalities, and the analysis of omics profiles of engineered strains to drive further iterations of the design cycle. All of these should be empowered by the latest advances in artificial intelligence and machine learning (AI/ML) where appropriate.
• Develop applied research, translational and commercialisation strategies, in coordination with the SRTT leadership team.
• Work closely with the other SIBER SRTT team members across disciplines
• Apply for individual research grants as part of career development and apply proactively for research proposals.
• Present findings at seminars, meetings and national / international conferences
• Write manuscripts for publication.
• Contribute to mentorship of PDRAs, students, interns and technicians in the laboratory
• Be an excellent communicator and team player.
• Build and maintain strong relationships with local and international research network.

Requirements:

• PhD in Computational Biology, Systems Biology, Bioinformatics, Cheminformatics, or a related field.
• At least more than 8 years of postdoc experience or independent research experience and leading a research team.
• Strong background in current developments in computational biology and systems biology, including relevant aspects of AI/ML, with demonstrated capability for independently developing and applying state-of-the-art tools for concrete biological applications at the cutting edge of the field.
• Extensive understanding of the key concepts and techniques of synthetic biology / engineering biology, molecular biology, biochemistry, chemical engineering, and process engineering.
• Track record of peer-reviewed scientific publications with at least five first-authored or last-authored papers in internationally recognised journals.
• Dedication, motivation, creativity and passion for scientific research and continuous learning.
• Exceptional analytical, experimental design, technical and problem-solving skills.
• Proficiency in communication, writing and editing scientific documents.
• Demonstrated ability to work independently as well as collaboratively and efficiently in an interdisciplinary team.
• Strong supervisory skills.
• A strong interest in the translational and applied aspects of research, including collaborations with industrial partners.
• Experience in omics technologies, HTP automation facilities, data analysis using various software, state-of-art med-scale fermenters or scale-up fermenters and programming will be a plus.

We offer:

• A well-funded laboratory supported by A*STAR, the National Research Foundation (NRF) and industry to pursue a combination of exciting projects and your scientific interests.
• A nurturing, supportive and stimulating environment with close mentorship to develop your scientific career.
• Access to state-of-the-art technologies, scientific resources, core facilities and infrastructure housed within A*STAR to facilitate your research work.
• Access to collaborations with industrial partners to translate research findings to commercial applications and societal impact.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Clinical Research Coordinator Job Opportunity

• We are seeking a highly organized and detail-oriented Clinical Research Coordinator to join our team.
• The successful candidate will play a vital role in ensuring the smooth conduct of clinical trials and research projects.

1. Assist Principal Investigators in conducting clinical trials and research projects according to Singapore Good Clinical Practice (GCP) guidelines
2. Plan, organize and coordinate workflow of study projects from initiation to completion phase
3. Perform screening and recruitment activities, compile relevant patients' data and maintain proper study documentation according to established protocols and regulatory requirements
4. Facilitate coordination of research studies with funding and regulatory bodies

• Lifesciences or Nursing Degree holder
• At least 1-2 years of experience in clinical research coordination
• Able to converse in mainstream languages to handle patient queries on the research study
• Strong organizational skills, able to work independently and/or as a team player, meticulous in details
• Proficient with MS Office applications

• Clinical Research
• Healthcare
• Administration
• Data Entry
• MS Office
• Clinical Trials
• Administrative Support
• Nursing
• Team Player
• Regulatory Requirements
• Lifesciences
• Screening
• Able To Work Independently

Benefits:

• Contribute to cutting-edge research that improves healthcare outcomes for patients
• Opportunity to work with a talented team

Additional Information:

You will have the opportunity to work on various projects and contribute to the growth and development of the organization.